Research funded by The Giorgio Foundation is featured in the June 2018 edition of Human Mutation. Another step closer to understanding what causes dermal neurofibromas to occur and what therapies can stop them…
The research of Dr. Lu Q. Le, as part of the Giorgio Foundation’s Dermal Neurofibroma Consortium has been included in an article in the British Journal of Cancer on April 26, 2018.
The article summarizes work that is being done to identify various gene mutations that cause dermal neurofibromas and how this research can be applied to cancer research. The Giorgio Foundation is on the frontier of this exciting new phase of research.
One of the challenges of NF1 is not knowing how you or or child will be impacted. There are so many different mutations of the gene and so many different outcomes. This news out of University of Wisconsin – Madison is very exciting. The associate director of the Biotechnology Center (and father of a son with NF1) is collaborating with other experts in the field to genetically modify pigs to have various mutations of the NF1 gene.
“Pigs develop faster than children do so they offer the possibility of helping predict how NF1 might affect a particular child, enabling parents, doctors, teachers and others to prepare. Earlier intervention for a child who develops autism could lead to better outcomes. Doctors could start working to find drugs to treat tumors before they grow too large.”
Read the entire fascinating article here:
The Blair County Convention Center was the setting for this year’s “An Evening to End NF1” fundraiser for The Giorgio Children’s Foundation (www.endnf1.org). The foundation raised $217,020 during the event, every dollar of which will go directly toward NF1 research, specifically for a treatment or cure for dermal neurofibromas (tumors). Also making this a memorable night was the introduction of renowned country singer/songwriter Josh Gallagher as the foundation’s Goodwill Ambassador.
“I couldn’t be more thrilled about the results of our fundraiser,” says Erin Borzellino, “and I’m equally enthusiastic about welcoming Josh Gallagher into our lives as the Goodwill Ambassador for The Giorgio Children’s Foundation. He earned the admiration of millions of viewers on ‘The Voice’ while turning in one fantastic performance after another. I look forward to the great advocacy work Josh will be doing on the foundation’s behalf.”
In June 2016, Gallagher auditioned for “The Voice,” NBC’s massively popular singing competition, joining approximately 43,000 other hopefuls across the nation. He not only made the cut — he eventually made his way into the final four contestants. In the process, he became a fan favorite owing not only to his songwriting abilities, but also his warm and relatable persona. Adam Levine and guest coach Garth Brooks both had high praise for Gallagher’s efforts after he finished in fourth place on the program; his remarkable success on “The Voice” gave him all the encouragement he needed to pursue his dream of a music career.
A native of Pennsylvania, Gallagher now calls Nashville home as he works to build his music career and give back to the fans who supported him on “The Voice.” In the Music City, Gallagher performs regularly at many of the city’s popular venues, including the Country Music Hall of Fame. To date, he has released two acoustic CDs and is now in the process of putting together a debut album.
In addition to a performance by Gallagher, “An Evening to End NF1” also featured the a cappella talents of “Pittch Please,” the University of Pittsburgh’s award-winning ensemble. By every measure, the night was a resounding success. Now, The Giorgio Children’s Foundation’s mission is to continue working to build awareness and fund important research.
About 1 in 3,000 children will be diagnosed with NF1. However, awareness of the condition is surprisingly low, which is why enlisting the support of public figures like Gallagher is so vital. NF1 is the result of a single defective gene that controls tumor growth, resulting in the development of tumors on and throughout the body in affected individuals.
About The Giorgio Children’s Foundation for NF1
The Giorgio Children’s Foundation was established in 2013 to fund research into a cure for NF1, specifically dermal neurofibromas. The foundation’s mission is to enhance understanding of this condition and empower focused research into treatments and cures for NF1.
With support from The Giorgio Foundation, scientists have isolated dermal tumors in mice and in petri dishes. They determined that these tumors require peripheral nerves to grow. Understanding the tumor microenvironment and the early stages of tumor growth is the most important first step to recognizing therapies.
Dig into the science in this article in Oncotarget Journal:
The “Dream Team” of NF1 researchers working with The Giorgio Foundation, Dr. David H. Gutmann, Dr. Lu Q. Le, and Dr. Robert A. Kesterson recently published a piece entitled “Defining the Research Landscape for Dermal Neurofibromas” in Oncology Times on Sept 26, 2016.
This piece summarizes some of the specific areas of research the NF1 Dermal Neurofibroma Consortium of these three doctors and their respective labs will be exploring in the coming years. The Giorgio Foundation is proud to be the sole source of funding for this cutting-edge research to find answers for some of the least understood aspects of NF1.